25-30 August 2019
Henry Ford Building
Europe/Berlin timezone

Manipulation of Spin Dynamics for Extraction of Spectral Parameters, Ultra High Resolution and Sensitivity Enhancement: Application to small molecules

30 Aug 2019, 09:20
Max Kade Auditorium (Henry Ford Building)

Max Kade Auditorium

Henry Ford Building

Plenary talk Small molecules Plenary Lectures


Prof. Nagaraja rao Suryaprakash (Indian Institute of Science)


The smaller chemical shift dispersion and the pairwise interaction among all the abundant nuclear spins of the molecule renders 1H NMR spectrum highly complex, severely hindering the straightforward analysis and the accurate determination of homo- and hetero- nuclear scalar couplings. The inherent insentitivy of NMR technique poses additional challenge. We have manipulated the spin dynamics and designed number of two dimensional techniques to partially address these problems. The developed NMR methodologies lead to the extraction of spectral parameters, resulted in ultra high resolution and enhanced sensitivity of 1H detection. My talk will be focused on the application of some of our experimental methods to derive specific information on the small molecules. The special emphasis will be on our novel techniqques, QG-SERF, Clean-G-SERF and PS-Clean-G-SERF. The QG-SERF permitted the rapid determiantion of spectral information, while the other two techniques completely eradicates the axial peaks and suppress the evolution of unwanted couplings while retaining only the couplings to the selectively excited proton thereby facilitating the accurate determination of indirect spin-spin couplings even from a complex proton NMR spectrum in an orchestrated manner.

Primary author

Prof. Nagaraja rao Suryaprakash (Indian Institute of Science)

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