25-30 August 2019
Henry Ford Building
Europe/Berlin timezone

Fragment Screening of a Kinase Target by 19F NMR: Hit Rate Comparison of 19F and 1H NMR Screens.

Not scheduled
4h
Harnack House and Henry Ford Building

Harnack House and Henry Ford Building

Board: 118
Poster Posters

Speaker

Dr Per-Olof Eriksson (Structure, Biophysics and Fragments, AstraZeneca)

Description

A fragment screen using ligand detected 19F NMR versus a kinase target will be described. In addition, practicalities of sample preparation and mixture design will be discussed. Furthermore, a TopSpin/Perl script package for automatic analysis of 19F NMR based screening data will be presented.

Primary authors

Dr Per-Olof Eriksson (Structure, Biophysics and Fragments, AstraZeneca) Dr Fredrik Edfeldt (Structure, Biophysics and Fragments, AstraZeneca Gothenburg) Dr Ulf Börjesson (Structure, Biophysics and Fragments, AstraZeneca Gothenburg)

Presentation Materials

There are no materials yet.