25-30 August 2019
Henry Ford Building
Europe/Berlin timezone

High-Field and Fast-MAS Solid-State NMR: Enabling Application to Pharmaceuticals and Supramolecular Assembly

29 Aug 2019, 10:30
35m
Lecture Hall D (Henry Ford Building)

Lecture Hall D

Henry Ford Building

Invited talk Solid-state NMR development and applications Solid-state NMR Methods

Speaker

Prof. Steven Brown (University of Warwick)

Description

Applications of advanced solid-state NMR methods for probing intermolecular interactions, notably hydrogen bonding are presented: Homonuclear 1H-1H double-quantum (DQ) experiments reveal proximities (typically under 3.5 Angstroms) among pairs of hydrogen atoms, for example distinguishing between ribbon-like or quartet-like self assembly in guanosine supramolecular structures [1-2] or pushing the limit of detection for a minority solid-state form of a pharmaceutical molecule [3]. 14N-1H spectra show one-bond NH connectivities or additionally longer-range NH proximities depending on the recoupling time employed: Applications to guanosine self assembly [4], a pharmaceutical [5] and to probe the stability of a fumarate salt [6] are shown.

  1. Peters, G. M. et al J. Am. Chem. Soc. 2015, 137, 5819.
  2. Reddy, G. N. M. et al Chem. Eur. J. 2017, 23, 2315.
  3. Maruyoshi, K. et al J. Pharm. Sci. 2017, 106, 3372.
  4. Reddy, G. N. M. et al Cryst. Growth Des. 2016, 15, 5945.
  5. Tatton, A. S. et al Cryst. Growth Des. 2018, 18, 3339.
  6. Corlett, E. K. et al CrystEngComm 2019, in press.

Primary author

Prof. Steven Brown (University of Warwick)

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