25-30 August 2019
Henry Ford Building
Europe/Berlin timezone

New methods and theory for conformatonal dynamics of macromolecules

26 Aug 2019, 10:30
Lecture Hall C (Henry Ford Building)

Lecture Hall C

Henry Ford Building

Invited talk Solution NMR development and applications Solution-state NMR Methods


Dr Arthur Palmer (Columbia University)


Spin relaxation in NMR spectroscopy is a powerful approach for probing aspects of conformational dynamics in biological macromolecules. Methods for characterizing dynamics on picosecond-nanosecond and on microsecond-millisecond time scales, emphasizing the information content provided by multiple static magnetic fields, are illustrated by applications to the enzyme ribonuclease H and the yeast transcription factor GCN4. Theoretical approaches generalize two-state descriptions of the $R_{1\rho}$, Carr-Purcell-Meiboom-Gill, and CEST experiments to N states with arbitrary kinetic topologies, facilitating applications to complex biological phenomena.

Primary author

Dr Arthur Palmer (Columbia University)

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