Sensitivity and resolution have been the two important traits in NMR of biomolecules. With the advent of cryogenically cooled probed and non-uniform sampling methods, the battle of sensitivity and resolution has to be revisited. 1H has long enjoyed the limelight due to its inherent sensitivity. The large gyromagnetic ratio of 1H it is nemesis when dealing high molecular weight systems since the dipolar contribution to relaxation is governed by the square of the gyromagnetic ratio. However, low gamma nuclei, though insensitive, have slower relaxation rates thus providing sharper resonances – a desired factor when dealing with a crowded spectrum. With reduced dipole-induced relaxation, the relaxation of the low gamma nuclei is often affected by chemical shift anisotropy (CSA). Here, we follow on the previously established TROSY effect-which cancels part of the CSA induced relaxation of the low-gamma nuclei using the dipole of the high-gamma nuclei- and develop 13C and 15N detected experiments for large molecular weight systems. The architecture, unique advantages and the limitations of these experiments will be presented.