Dynamic Nuclear Polarization (DNP) has recently evolved into a cornerstone technology to overcome the sensitivity limitations of solid-state NMR. This technique, originally developed for low magnetic fields, has been shown to be applicable at high fields, opening new avenues in materials and life sciences. In this presentation we will review some recent advances from high magnetic field (18.8 T) and fast Magic Angle Spinning (MAS) (~ 40 kHz) DNP NMR. In particular, we will present our efforts towards the development of polarizing agents tailored for efficient DNP at high fields and fast MAS. Applications to the characterization of challenging catalytic surfaces and of biological assemblies will also be presented.