25-30 August 2019
Henry Ford Building
Europe/Berlin timezone

Copper trafficking in eukaryotic systems: Current knowledge from experimental and computational efforts

26 Aug 2019, 16:15
Lecture Hall C (Henry Ford Building)

Lecture Hall C

Henry Ford Building

Invited talk Biological applications Biomolecules


Prof. Sharon Ruthstein (Bar Ilan University)


Copper plays a vital role in fundamental cellular functions, and its concentration in the cell must be tightly regulated, as dysfunction of copper homeostasis is linked to severe neurological diseases and cancer. This talk provides a compendium of current knowledge regarding the mechanism of copper transfer from the blood system to the Golgi apparatus; this mechanism involves the blood carrier protein, human serum albumin (HSA), the copper transporter hCtr1, the metallochaperone Atox1, and the ATPases ATP7A/B. I will discuss key insights regarding the structural and functional properties of the hCtr1-Atox1-ATP7B cycle, obtained from diverse studies relying on Electron Paramagnetic Resonance (EPR) measurements, complementary biophysical methods, biochemical, and computational methods. Last, I will demonstrate how basic under-standing of the function of these systems can assist us in designing new class of bi-markers and therapeutic agents.

Primary author

Prof. Sharon Ruthstein (Bar Ilan University)

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