25-30 August 2019
Henry Ford Building
Europe/Berlin timezone

Everyone needs a little help from one’s friends: Synergy between NMR, cryo-EM and large-Scale MD Simulations

25 Aug 2019, 17:40
20m
Max Kade Auditorium (Henry Ford Building)

Max Kade Auditorium

Henry Ford Building

Prize lecture Biological applications Prize Lectures

Speaker

Prof. Angela M. Gronenborn (University of Pittsburgh School of Medicine)

Description

Those of us engaged in active experimental research careers rarely have the opportunity to step back from the lab bench or the computer to reflect on our own scientific practice. Long before descriptive terms such as “multidisciplinary” or “integrative” were fashionable, biological NMR (BioNMR), from its very beginnings, was multidisciplinary in and by itself. Integration of complementary data has a long history in BioNMR and by now everyone in the scientific community is well aware that single types of methodologies are insufficient to adequately describe complex biological structures. I will describe the benefits of integrating solution NMR, MAS solid state NMR, crystallography, cryoEM and large-scale MD simulation, which permitted us to derive a realistic all-atom model for the entire HIV-1 capsid.

Primary author

Prof. Angela M. Gronenborn (University of Pittsburgh School of Medicine)

Presentation Materials

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